Events
Welcome to the events! Here you will have access to resources that other organizations and universities have developed for you to learn more about your mind. There will be various available events, that will help you gain valuable insight into the world of neurology and psychology.
Boundary IQ
October 23rd | 11:00am EDT | Mindspring Mental Health Alliance
Creating and maintaining healthy boundaries can be a challenging task. Some people grew up in environments where setting boundaries was not emphasized or valued, resulting in struggles to establish boundaries in adulthood. Fear of conflict, a tendency to prioritize others’ approval, or past experiences of invalidation or disrespect can also contribute to difficulties in setting and maintaining boundaries. Discuss the role of boundaries in relationships and learn how to implement healthy boundaries in this one-hour seminar sponsored by Polk County, Iowa.
The Power of Dynamic Analyses in Biofilm Research
October 23rd | 10:00am EDT | Technology Networks
Biofilms are three-dimensional communities of microbes attached to a surface or to each other. Most researchers are very aware of biofilms’ spatial heterogeneity; however, their heterogeneity in time is usually ignored.
Accelerating insights into changes in binding affinity of biomolecular charge variants using a simple icIEF fractionation and SPR workflow
October 30th | 02:00pm EDT | LabRoots and Nicoya Lifesciences
Charge heterogeneity in monoclonal antibodies can negatively impact binding affinity and potency, so it is critical to ensure that individual charge variants of biotherapeutic molecules are thoroughly characterized to ensure product quality. Dr. Chris Heger (Bio-Techne) and Dr. Mike Piazza (Nicoya Lifesciences) will illustrate a fast, simple icIEF fractionation and digital SPR workflow that provides in-depth characterization of the charge variants of a therapeutic bispecific antibody (BsAb) Mosunetuzumab and a research-grade biosimilar. Using a combination of the MauriceFlex™ system and Alto™ Digital SPR, they demonstrate a novel method that utilizes imaged capillary isoelectric focusing (icIEF)-based charge separation and fractionation followed by binding affinity analysis using surface plasmon resonance, offering a robust and efficient approach to evaluating charge variants. Prior LC-MS analysis of the fractions uncovered interesting differences between the two molecules. The speakers will show how the high-purity fractions of both the innovator drug and a research-grade biosimilar were analyzed by SPR for binding studies with their ligands CD3 and CD20, revealing notable differences in binding affinity, particularly between the biosimilar’s acidic peak and ligand CD20.